سعر ايزو اكنيتين 20مجم 30 كبسولة 2024

Iso-acnetin 20 mg (Sigma): isotretinoin 20 mg oral capsules, pack of 30 (3 strips); a systemic retinoid used for acne.

• Severe forms of acne (nodular or conglobate acne, or acne at risk of permanent scarring) resistant to adequate courses of standard therapy with systemic antibacterials and topical therapy.Population: Adolescents (12 years and older) and adultselectronic medicines compendium (emc), UK
• Severe recalcitrant nodular acne (multiple inflammatory nodules of 5 mm or greater) unresponsive to conventional therapy including systemic antibiotics, in non-pregnant patients aged 12 years and older.Population: Non-pregnant patients 12 years and olderDailyMed (U.S. National Library of Medicine)

• Most common: dryness of skin and mucosae (cheilitis, epistaxis, conjunctivitis). Very common: anaemia, thrombocytopenia/thrombocytosis, blepharitis, dry eye, raised transaminases, pruritus, rash, dermatitis, skin fragility, arthralgia, myalgia, back pain, raised triglycerides and reduced HDL. Common: headache, nasopharyngitis, nasal dryness, neutropenia, raised cholesterol and glucose, haematuria, proteinuria. Rare/very rare: depression and suicidal behaviour, benign intracranial hypertension, visual disturbances, pancreatitis, inflammatory bowel disease, hepatitis, severe skin reactions; not known: sexual dysfunction, rhabdomyolysis, sacroiliitis.International label, same formulation · electronic medicines compendium (emc), UK

• Pregnancy and breastfeeding; women of childbearing potential unless all conditions of the Pregnancy Prevention Programme are met; hypersensitivity to isotretinoin or excipients (UK product contains soya oil, so contraindicated in peanut or soya allergy); hepatic insufficiency; excessively elevated blood lipids; hypervitaminosis A; concomitant tetracyclines.International label, same formulation · electronic medicines compendium (emc), UK
• US label: contraindicated in pregnancy and in patients with hypersensitivity to isotretinoin (or vitamin A) or any of its components.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Powerful human teratogen: strict Pregnancy Prevention Programme (effective contraception from 1 month before to 1 month after treatment, medically supervised pregnancy tests before, monthly during and 1 month after). Psychiatric effects (depression, anxiety, suicidal ideation) and sexual dysfunction: assess and monitor. Avoid intense sunlight/UV, wax depilation, dermabrasion and laser for 5-6 months after treatment. Severe skin reactions (SJS/TEN, AGEP), benign intracranial hypertension, decreased night vision and dry eyes, myalgia/raised CK, inflammatory bowel disease, raised liver enzymes and lipids (pancreatitis if triglycerides very high), raised blood glucose. Do not donate blood during and for 1 month after therapy.International label, same formulation · electronic medicines compendium (emc), UK
• US boxed warning: embryo-fetal toxicity; contraindicated in pregnancy. Available in the US only through the iPLEDGE REMS restricted program; dispense no more than a 30-day supply.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Vitamin ARisk of hypervitaminosis A; do not take vitamin A concurrently.electronic medicines compendium (emc), UK
• TetracyclinesCases of benign intracranial hypertension (pseudotumor cerebri); concomitant use is contraindicated.electronic medicines compendium (emc), UK
• Topical keratolytic or exfoliative anti-acne agentsLocal irritation may increase; avoid concurrent use.electronic medicines compendium (emc), UK

• Pregnancy is an absolute contraindication: very high risk of severe malformations (CNS, facial, cleft palate, ear, eye, cardiovascular, thymus and parathyroid abnormalities) and increased spontaneous abortion; the risk persists until about one month after stopping treatment.International label, same formulation · electronic medicines compendium (emc), UK
• US label: can cause life-threatening birth defects; contraindicated in pregnancy; pregnancy testing is required before, during and after treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Highly lipophilic, passage into milk very likely; contraindicated during breastfeeding.International label, same formulation · electronic medicines compendium (emc), UK

• Isotretinoin: Stereoisomer of all-trans retinoic acid; suppresses sebaceous gland activity and reduces gland size, normalises follicular keratinisation and has a dermal anti-inflammatory effect; exact mechanism not fully elucidated.