سعر ليبترين 10/10 مجم 2022

Lipitrin 10/10 mg 14 tablets (Chemipharm, Egypt): tablets combining ezetimibe 10 mg and simvastatin 10 mg (strength figures interpreted as ezetimibe/simvastatin).

• Adjunct to diet to reduce elevated LDL-C in adults with primary hyperlipidaemia and in adults and children aged 10 years and older with HeFH; adjunct to other LDL-C-lowering therapies in adults with HoFH.Population: Adults and children aged 10 years and olderDailyMed (U.S. National Library of Medicine)

• Common (2% or more and greater than placebo) in clinical trials: headache, increased ALT, myalgia, upper respiratory tract infection, diarrhoea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant strong CYP3A4 inhibitors (select azole antifungals, macrolide antibiotics, antivirals, nefazodone); ciclosporin or danazol (the label highlights also list gemfibrozil); acute liver failure or decompensated cirrhosis; hypersensitivity to simvastatin, ezetimibe or any excipient.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis (risk factors: age 65 or older, uncontrolled hypothyroidism, renal impairment, certain concomitant drugs, higher dosage; Chinese patients may be at higher risk); discontinue if markedly elevated CK or myopathy suspected; immune-mediated necrotising myopathy; hepatic dysfunction; increases in HbA1c and fasting glucose.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors, ciclosporin, danazolContraindicated (increased simvastatin exposure and myopathy/rhabdomyolysis risk).DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognised, or consider the ongoing therapeutic needs; may cause fetal harm based on mechanism of action; treatment of hyperlipidaemia is not generally necessary during pregnancy.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on presence of ezetimibe or simvastatin in human milk; other statins pass into milk; breastfeeding is not recommended during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Ezetimibe: Inhibits intestinal absorption of cholesterol and related phytosterols by binding the sterol transporter NPC1L1 at the small-intestinal brush border.
• Simvastatin: Inactive lactone hydrolysed to the beta-hydroxyacid form, which competitively inhibits HMG-CoA reductase and reduces hepatic cholesterol synthesis.