سعر لوسترال 50مجم 10 قرص 2023

Lustral 50 mg film-coated tablets (10) by Pfizer/Viatris (Egypt): sertraline, a selective serotonin reuptake inhibitor (SSRI) antidepressant.

• Major depressive episodes and prevention of recurrence of major depressive episodes.Population: Adultselectronic medicines compendium (emc)
• Panic disorder, with or without agoraphobia.Population: Adultselectronic medicines compendium (emc)
• Obsessive compulsive disorder (OCD) in adults and paediatric patients aged 6-17 years.Population: Adults and children aged 6-17 yearselectronic medicines compendium (emc)

• Very common (≥1/10): headache (22%), insomnia (21%), nausea (15%) and diarrhoea (11%); other frequent effects include dizziness, somnolence, dry mouth, ejaculation failure and fatigue.International label, same formulation · electronic medicines compendium (emc)
• Most common adverse reactions in US trials: nausea, diarrhoea/loose stool, tremor, dyspepsia, decreased appetite, hyperhidrosis, ejaculation failure and decreased libido.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to sertraline or any of the excipients.International label, same formulation · electronic medicines compendium (emc)
• Concomitant irreversible MAOIs (risk of serotonin syndrome): do not start sertraline within 14 days of stopping an irreversible MAOI, and stop sertraline at least 7 days before starting one.International label, same formulation · electronic medicines compendium (emc)
• Concomitant pimozide.International label, same formulation · electronic medicines compendium (emc)

• Boxed warning: antidepressants increase the risk of suicidal thoughts and behaviours in paediatric and young adult patients; monitor closely for clinical worsening and emergence of suicidal thoughts, especially early in treatment and after dose changes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serotonin syndrome or neuroleptic malignant syndrome, especially with other serotonergic drugs; QTc prolongation and torsade de pointes; activation of mania/hypomania; seizures; akathisia.International label, same formulation · electronic medicines compendium (emc)
• Abnormal bleeding (especially with anticoagulants, antiplatelets or NSAIDs), hyponatraemia (especially in the elderly), sexual dysfunction that may persist after stopping, angle-closure glaucoma, altered glycaemic control in diabetes, and withdrawal reactions on discontinuation.International label, same formulation · electronic medicines compendium (emc)

• Irreversible MAOIs, moclobemide, linezolidRisk of serotonin syndrome; irreversible MAOIs are contraindicated, and reversible or non-selective MAOIs such as moclobemide and linezolid should not be combined with sertraline.electronic medicines compendium (emc)
• PimozideContraindicated: sertraline increases pimozide levels.electronic medicines compendium (emc)
• Other serotonergic drugs (e.g. triptans, tramadol, fentanyl, lithium)Increased risk of serotonin syndrome; use with caution.electronic medicines compendium (emc)

• Not recommended in pregnancy unless the clinical benefit is expected to outweigh the potential risk; substantial data did not show congenital malformations; observational data indicate an increased risk (less than 2-fold) of postpartum haemorrhage with exposure in the month before birth.International label, same formulation · electronic medicines compendium (emc)
• Small quantities of sertraline and N-desmethylsertraline are excreted in milk, with generally negligible infant serum levels; a risk cannot be excluded, so use in nursing mothers is not recommended unless the benefit outweighs the risk.International label, same formulation · electronic medicines compendium (emc)

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