سعر سيرتو 50مجم 10 اقراص 2023

Sirto 50 mg film-coated tablets, pack of 10 (Hi-Pharm, Egypt): sertraline, a selective serotonin reuptake inhibitor (SSRI) antidepressant.

• Major depressive disorder (MDD)Population: AdultsDailyMed (U.S. National Library of Medicine)
• Obsessive-compulsive disorder (OCD)Population: Adults and pediatric patients aged 6 years and olderDailyMed (U.S. National Library of Medicine)
• Panic disorderPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (>=5% and twice placebo): nausea, diarrhoea/loose stool, tremor, dyspepsia, decreased appetite, hyperhidrosis, ejaculation failure and decreased libido.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant use of MAOIs or within 14 days of stopping an MAOI (including linezolid or intravenous methylene blue); concomitant pimozide; known hypersensitivity to sertraline (e.g. anaphylaxis, angioedema). (The US oral solution is additionally contraindicated with disulfiram; not relevant to tablets.)International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• BOXED WARNING: increased risk of suicidal thoughts and behaviours in pediatric and young adult patients taking antidepressants; closely monitor all antidepressant-treated patients for clinical worsening and emergence of suicidal thoughts and behaviours.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Serotonin syndrome (especially with other serotonergic drugs); increased bleeding risk with aspirin, NSAIDs, warfarin and other anticoagulants; activation of mania/hypomania (screen for bipolar disorder); discontinuation syndrome; seizures; angle-closure glaucoma; hyponatraemia; QTc prolongation and torsade de pointes; sexual dysfunction.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• MAOIs (including linezolid, intravenous methylene blue)Risk of serotonin syndrome; contraindicated, 14-day washout required.DailyMed (U.S. National Library of Medicine)
• PimozideIncreased pimozide concentrations with QTc prolongation risk; contraindicated.DailyMed (U.S. National Library of Medicine)
• Other serotonergic drugs (triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, meperidine, methadone, tryptophan, buspirone, amphetamines, St John's Wort)Increased risk of serotonin syndrome; monitor.DailyMed (U.S. National Library of Medicine)

• Available data from published observational studies, primarily first-trimester exposure, have not identified an increased risk of major birth defects overall. Use in the month before delivery may be associated with an increased risk of postpartum haemorrhage. Untreated depression in pregnancy carries risks.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Sertraline is present in human milk at low levels; consider the benefits of breastfeeding, the mother's clinical need and potential adverse effects on the infant.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Sertraline: Presumed to be linked to inhibition of CNS neuronal uptake of serotonin (5-HT).