سعر ميتروزول 125مجم/5مل معلق 120 مل 2024

Metronidazole 125 mg/5 ml oral suspension, 120 ml bottle (Metrozole, Memphis).

• Most common: gastrointestinal effects (nausea, sometimes with headache, anorexia, vomiting, diarrhoea, epigastric distress, abdominal cramping) and an unpleasant metallic taste; serious: seizures, encephalopathy, aseptic meningitis, peripheral and optic neuropathy.General active-ingredient information · DailyMed (US National Library of Medicine)

• Hypersensitivity to metronidazole or other nitroimidazole derivatives.General active-ingredient information · DailyMed (US National Library of Medicine)
• Do not give to patients who have taken disulfiram within the last two weeks (psychotic reactions).General active-ingredient information · DailyMed (US National Library of Medicine)
• Avoid alcohol and products containing propylene glycol during therapy and for at least three days afterwards (disulfiram-like reaction).General active-ingredient information · DailyMed (US National Library of Medicine)
• Cockayne syndrome (severe irreversible hepatotoxicity and fatal acute liver failure reported).General active-ingredient information · DailyMed (US National Library of Medicine)

• Metronidazole is carcinogenic in mice and rats; avoid unnecessary use and reserve for labelled indications.General active-ingredient information · DailyMed (US National Library of Medicine)
• Severe cutaneous adverse reactions (SJS, TEN, DRESS, AGEP) can occur; stop immediately if they develop.General active-ingredient information · DailyMed (US National Library of Medicine)
• Encephalopathy, peripheral and optic neuropathy, convulsive seizures and aseptic meningitis have been reported; stop the drug if neurological symptoms occur.General active-ingredient information · DailyMed (US National Library of Medicine)

• DisulfiramPsychotic reactions in alcoholic patients using both; do not give metronidazole within two weeks of disulfiram.DailyMed (US National Library of Medicine)
• Alcohol / propylene glycolAbdominal cramps, nausea, vomiting, headache and flushing may occur.DailyMed (US National Library of Medicine)
• Warfarin and other oral coumarin anticoagulantsAnticoagulant effect is potentiated; monitor prothrombin time/INR closely.DailyMed (US National Library of Medicine)
• LithiumSerum lithium may rise with toxicity; check serum lithium and creatinine several days after starting.DailyMed (US National Library of Medicine)
• BusulfanMetronidazole can increase busulfan concentrations and serious busulfan toxicity; avoid the combination unless benefit outweighs risk.DailyMed (US National Library of Medicine)

• Data on more than 5,000 exposed pregnancies (many in the first trimester) generally show no consistent increase in congenital anomalies; one unconfirmed cleft-lip signal; metronidazole crosses the placenta.General active-ingredient information · DailyMed (US National Library of Medicine)
• Present in human milk at concentrations similar to maternal serum; a nursing mother may pump and discard milk during therapy and for 48 hours after the last dose.General active-ingredient information · DailyMed (US National Library of Medicine)

• Metronidazole: After passive diffusion into susceptible anaerobes it is reduced intracellularly (via electron-transport proteins such as ferredoxin) to a short-lived nitroso free radical; the reduced drug and free radicals can interact with DNA, inhibiting DNA synthesis and causing DNA degradation and bacterial death; the precise mechanism is unclear (US label).