سعر نورتنس 5مجم 20 اقراص 2022

Amlodipine 5 mg tablets, pack of 20 (Logestic Pharma, Egypt); dihydropyridine calcium channel blocker for hypertension and angina.

• Hypertension, to lower blood pressure (alone or with other antihypertensives)Population: Adults and children 6-17 yearsDailyMed (U.S. National Library of Medicine)
• Coronary artery disease: chronic stable angina, vasospastic angina, and angiographically documented CAD (to reduce hospitalisation for angina and revascularisation)Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common: dose-related oedema; also fatigue, nausea, abdominal pain and somnolence.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known sensitivity to amlodipine.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Symptomatic hypotension is possible, particularly in severe aortic stenosis; worsening angina and acute myocardial infarction can develop on starting or increasing the dose, particularly in severe obstructive coronary artery disease.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Overdose may cause excessive peripheral vasodilation with marked hypotension and possibly reflex tachycardia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CYP3A inhibitors (moderate and strong)Increase amlodipine exposure; may require dose reduction - monitor for hypotension and oedema.DailyMed (U.S. National Library of Medicine)
• SimvastatinAmlodipine increases simvastatin exposure; limit simvastatin to 20 mg daily.DailyMed (U.S. National Library of Medicine)
• Cyclosporine, tacrolimusAmlodipine may increase their exposure; monitor trough levels frequently.DailyMed (U.S. National Library of Medicine)

• Limited post-marketing data are insufficient to inform a drug-associated risk of major birth defects or miscarriage; poorly controlled hypertension in pregnancy carries maternal and fetal risks.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Amlodipine is present in human milk; estimated median relative infant dose 4.2%. No adverse effects on the breastfed infant were observed in limited data.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amlodipine: Inhibits transmembrane calcium influx into vascular smooth muscle and cardiac muscle; peripheral arterial vasodilator.