سعر ستاندازيل بلس 40/12.5 مجم 10 أقراص مغلفة 2022

Standazil plus 40/12.5 mg film-coated tablets (Rameda, Egypt), pack of 10: fixed combination of azilsartan (angiotensin II receptor blocker) and chlortalidone (thiazide-like diuretic) for hypertension.

• Treatment of hypertension, including patients not adequately controlled on monotherapy, or as initial therapy if multiple drugs are likely to be needed.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Adverse reactions in >=2% and more than either component in the factorial trial: dizziness (8.9%) and fatigue (2.0%); hypotension 1.7% and syncope 0.3%.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Anuria.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Do not co-administer aliskiren-containing products in patients with diabetes.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Fetal toxicity (boxed warning): discontinue when pregnancy is detected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Symptomatic hypotension in volume- or salt-depleted patients; correct volume before starting.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Serum electrolyte imbalances: chlorthalidone can cause hyponatraemia and dose-dependent hypokalaemia; RAS inhibition can cause hyperkalaemia; monitor electrolytes periodically.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• NSAIDs including COX-2 inhibitorsMay deteriorate renal function in elderly, volume-depleted or renally impaired patients and attenuate the antihypertensive effect; monitor renal function.DailyMed (U.S. National Library of Medicine)
• ACE inhibitors, other ARBs, aliskiren (dual RAS blockade)Increased risk of hypotension, hyperkalaemia and renal impairment; avoid combined RAS inhibition; no aliskiren in diabetes; avoid aliskiren if GFR <60 mL/min.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased lithium levels and toxicity (ARB effect plus reduced renal lithium clearance by chlorthalidone); monitor lithium levels.DailyMed (U.S. National Library of Medicine)

• Boxed warning - fetal toxicity: drugs acting on the renin-angiotensin system can cause fetal injury and death; discontinue as soon as pregnancy is detected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Azilsartan is present in rat milk and chlorthalidone is excreted in human milk; breastfeeding is not recommended during treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Azilsartan (directory; US reference product contains azilsartan medoxomil as potassium salt): Azilsartan medoxomil is a prodrug hydrolysed during absorption to azilsartan, which selectively blocks angiotensin II binding to the AT1 receptor, inhibiting its vasoconstrictor and aldosterone-secreting effects.
• Chlortalidone (chlorthalidone): Monosulfamyl thiazide-like diuretic that increases urinary sodium and chloride excretion.