سعر تريكونال Triconal‏ 150مجم 1 كبسول 2026

Fluconazole 150 mg hard capsule, pack of 1 capsule, by T3A Pharma (Egypt; listed as "T3a pharma > Vodachem pharmaceuticals"); oral triazole antifungal.

• Most frequent (1-10%): headache, abdominal pain, diarrhoea, nausea, vomiting, raised ALT/AST/alkaline phosphatase and rash.International label, same formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to fluconazole, related azoles or any excipient.International label, same formulation · electronic medicines compendium (emc), UK
• Co-administration with QT-prolonging CYP3A4 substrates such as cisapride, astemizole, pimozide, quinidine and erythromycin; terfenadine with fluconazole multiple doses of 400 mg/day or more.International label, same formulation · electronic medicines compendium (emc), UK

• Rare serious hepatotoxicity, including fatal cases, has been reported; discontinue if signs of liver disease develop.International label, same formulation · electronic medicines compendium (emc), UK
• QT prolongation and torsades de pointes have been reported; use with caution in patients with proarrhythmic conditions.International label, same formulation · electronic medicines compendium (emc), UK
• Severe cutaneous reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS) and adrenal insufficiency have been reported. Not for tinea capitis.International label, same formulation · electronic medicines compendium (emc), UK

• Cisapride, astemizole, pimozide, quinidine, erythromycinContraindicatedIncreased plasma levels with risk of QT prolongation and torsades de pointes; concomitant use contraindicated.electronic medicines compendium (emc), UK
• Warfarin and other coumarin-type anticoagulantsProthrombin time prolonged up to 2-fold (CYP2C9 inhibition); monitor prothrombin time and adjust the anticoagulant dose if needed.electronic medicines compendium (emc), UK
• RifampicinDecreases fluconazole AUC by about 25% and shortens half-life by 20%; consider increasing the fluconazole dose.electronic medicines compendium (emc), UK

• Observational studies suggest an increased risk of spontaneous abortion with fluconazole in the first and/or second trimester; a small increased risk of musculoskeletal and (in a meta-analysis) cardiac malformations has been reported after first-trimester exposure. Standard-dose short courses should not be used in pregnancy unless clearly necessary.International label, same formulation · electronic medicines compendium (emc), UK
• High-dose (400-800 mg/day) long-term treatment in pregnancy has been associated with a specific pattern of birth defects; a washout of about 1 week (5-6 half-lives) is recommended before pregnancy.International label, same formulation · electronic medicines compendium (emc), UK
• Fluconazole passes into breast milk at concentrations similar to plasma; breast-feeding may be maintained after a single 150 mg dose but is not recommended after repeated or high-dose use.International label, same formulation · electronic medicines compendium (emc), UK

• Fluconazole: Inhibits fungal cytochrome P450-mediated 14-alpha-lanosterol demethylation, an essential step in ergosterol biosynthesis.