سعر افيفافاسك 10/160مجم 28 قرص 2024

Fixed-dose combination of amlodipine 10 mg and valsartan 160 mg in film-coated tablets (Avivavasc, Marcyrl Co. / Ecco Pharm, Egypt), combining a dihydropyridine calcium channel blocker with an angiotensin II receptor blocker; pack of 28 tablets (4 strips).

• Treatment of hypertension, to lower blood pressure, in patients not adequately controlled on monotherapy.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Initial therapy of hypertension in patients likely to need multiple drugs to achieve blood pressure goals.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Adverse reactions occurring in 2% or more of patients at a higher incidence than placebo: peripheral oedema, nasopharyngitis, upper respiratory tract infection and dizziness; the most common reasons for discontinuation were peripheral oedema and vertigo.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to any component.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Do not coadminister aliskiren with this combination in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fetal toxicity: discontinue as soon as possible when pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypotension: correct volume or salt depletion before starting; initiate cautiously in heart failure, recent myocardial infarction, surgery or dialysis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Worsening angina and acute myocardial infarction can develop after starting or increasing amlodipine, particularly in severe obstructive coronary artery disease.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Moderate and strong CYP3A inhibitorsIncrease systemic amlodipine exposure and may require dose reduction; monitor for hypotension and oedema.DailyMed (U.S. National Library of Medicine)
• CYP3A inducers (e.g. rifampicin, St John's wort)Blood pressure should be closely monitored when coadministered with amlodipine.DailyMed (U.S. National Library of Medicine)
• SimvastatinAmlodipine increases simvastatin exposure; limit simvastatin to 20 mg daily.DailyMed (U.S. National Library of Medicine)

• Boxed warning - fetal toxicity: drugs acting directly on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as possible when pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment: valsartan is present in rat milk and limited published studies report amlodipine in human milk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amlodipine: Inhibits transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, acting as a peripheral arterial vasodilator that lowers peripheral vascular resistance.
• Valsartan: Blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking its binding to the AT1 receptor.