سعر انتاكافير 1مجم 10 اقراص 2022

Entecavir 1 mg 10 tab (entecavir), Penta Pharma-Egypt.

• Chronic hepatitis B virus infection in adults and children ≥2 years with active viral replication and persistently raised ALT/AST or histologically active disease (US label).Population: Adults and children ≥2 yearsDailyMed / FDA

• Most common in adults (≥3%): headache, fatigue, dizziness and nausea; pediatric profile consistent with adults (US label).International label, same formulation · DailyMed / FDA

• Boxed warning: severe acute exacerbations of hepatitis B after discontinuation; monitor hepatic function closely for at least several months after stopping (US label).International label, same formulation · DailyMed / FDA
• Boxed warning: in HIV/HBV co-infection not on effective HIV treatment, risk of HIV nucleoside resistance; offer HIV testing before starting (US label).International label, same formulation · DailyMed / FDA
• Boxed warning: lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, reported with nucleoside analogues (US label).International label, same formulation · DailyMed / FDA

• Drugs that reduce renal function or compete for active tubular secretionMay increase serum concentrations of entecavir or the co-administered drug; monitor closely (US label).DailyMed / FDA

• Antiretroviral Pregnancy Registry data are insufficient to assess the risk of birth defects, miscarriage or adverse maternal/fetal outcomes; a pregnancy exposure registry exists (US label).International label, same formulation · DailyMed / FDA
• Unknown whether present in human milk (present in rat milk at about 25% of plasma); weigh breastfeeding benefits against maternal need and potential infant effects (US label).International label, same formulation · DailyMed / FDA

• Entecavir: Guanosine nucleoside analogue; the triphosphate competes with deoxyguanosine triphosphate and inhibits HBV polymerase base priming, reverse transcription of the negative strand and positive-strand HBV DNA synthesis.