سعر لودنوفير 0.5مجم 10اقراص 2022

Ludnovir (Mash Premiere) entecavir 0.5 mg tablets, pack of 10: an oral nucleoside analogue inhibitor of hepatitis B virus polymerase used for chronic hepatitis B.

• Chronic hepatitis B virus infection in adults and paediatric patients 2 years and older with evidence of active viral replication and either persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.Population: Adults and children 2 years and olderDailyMed (U.S. National Library of Medicine)

• Most common (>=3%, compensated liver disease trials): headache, fatigue, dizziness and nausea. Moderate-to-severe related reactions were infrequent (headache 2-4%, fatigue 1-3%; diarrhoea, dyspepsia, vomiting, somnolence and insomnia about 1% or less).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• None (US label).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: severe acute exacerbations of hepatitis B after discontinuation of anti-hepatitis B therapy; monitor hepatic function closely for at least several months after stopping.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: not recommended in HIV/HBV co-infected patients not receiving HAART because of possible HIV resistance to nucleoside reverse transcriptase inhibitors; offer HIV testing before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, with nucleoside analogues; suspend treatment if clinical or laboratory signs occur (higher risk in decompensated liver disease).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Drugs that reduce renal function or compete for active tubular secretionMay increase serum concentrations of entecavir or the co-administered drug; monitor closely for adverse events. Co-administration with lamivudine, adefovir dipivoxil or tenofovir disoproxil fumarate showed no significant interaction.DailyMed (U.S. National Library of Medicine)

• Antiretroviral Pregnancy Registry data are insufficient to assess the risk of birth defects or miscarriage; no adverse developmental effects in animal studies at clinically relevant exposures.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Unknown whether present in human milk; present in rat milk (about 25% of maternal plasma). Weigh breastfeeding benefits against maternal need and possible infant effects.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Entecavir: Guanosine nucleoside analogue; its triphosphate competes with deoxyguanosine triphosphate and inhibits HBV polymerase base priming, reverse transcription of the negative strand and synthesis of the positive strand of HBV DNA.