سعر هيبسيرا 10 مجم 30 قرص 2022

Adefovir dipivoxil 10 mg tablets, pack of 30 (GlaxoSmithKline).

• Chronic hepatitis B in patients 12 years and older with active viral replication and persistently elevated ALT/AST or histologically active disease.Population: Patients >= 12 yearsDailyMed (U.S. National Library of Medicine)

• Most common (>10%): asthenia in compensated disease; increased creatinine in pre-/post-transplant lamivudine-resistant patients.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Previously demonstrated hypersensitivity to any component of the product.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: severe acute exacerbations of hepatitis after discontinuation; monitor hepatic function closely for at least several months after stopping.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: nephrotoxicity, especially in patients at risk of or with renal dysfunction; monitor renal function.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: HIV resistance may emerge in unrecognised or untreated HIV infection; offer HIV testing before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Drugs that reduce renal function or compete for active tubular secretionMay increase serum concentrations of adefovir and/or the co-administered drug; monitor.DailyMed (U.S. National Library of Medicine)
• Tenofovir disoproxil fumarateShould not be used concurrently.DailyMed (U.S. National Library of Medicine)

• No adequate and well-controlled studies in pregnant women; use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregnancy registry available; use appropriate infant immunisation to prevent neonatal HBV acquisition.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Unknown whether adefovir is excreted in human milk; decide whether to discontinue nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Adefovir dipivoxil: Prodrug of adefovir; adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with deoxyadenosine triphosphate and causing DNA chain termination.