سعر هايزار 100/12.5مجم 14 قرص 2022

Hyzaar 100/12.5 mg film-coated tablets (pack of 14): fixed combination of the angiotensin II receptor blocker losartan and the thiazide diuretic hydrochlorothiazide, marketed in Egypt by MSD (Multipharma) for hypertension.

• Hypertension, to lower blood pressure (not for initial therapy except as labeled).DailyMed (U.S. National Library of Medicine)
• Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy (benefit may not apply to Black patients).DailyMed (U.S. National Library of Medicine)

• In controlled trials, adverse reactions more frequent than placebo (>2%) were dizziness (5.7%), upper respiratory infection (6.1%) and back pain (2.1%).International label, same product · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any component; anuria; co-administration with aliskiren in patients with diabetes.International label, same product · DailyMed (U.S. National Library of Medicine)

• Boxed warning - fetal toxicity: drugs acting on the renin-angiotensin system can cause fetal injury and death; discontinue as soon as pregnancy is detected.International label, same product · DailyMed (U.S. National Library of Medicine)
• Symptomatic hypotension in volume- or salt-depleted patients; correct depletion before starting.International label, same product · DailyMed (U.S. National Library of Medicine)
• Impaired renal function, including acute renal failure, in at-risk patients (renal artery stenosis, CKD, severe heart failure, volume depletion); monitor renal function.International label, same product · DailyMed (U.S. National Library of Medicine)

• Potassium-raising drugsCo-administration with drugs that raise serum potassium may cause hyperkalemia; monitor potassium.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium and lithium toxicity reported with ARBs or thiazides; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• Aliskiren / ACE inhibitors / other ARBs (dual RAS blockade)Dual RAS blockade increases hypotension, hyperkalemia and renal function changes; do not co-administer aliskiren in diabetes and avoid it if GFR < 60 mL/min.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm; RAS-acting drugs in the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death. Discontinue as soon as pregnancy is detected.International label, same product · DailyMed (U.S. National Library of Medicine)
• Unknown whether losartan is excreted in human milk; thiazides appear in human milk. Decide whether to discontinue nursing or the drug.International label, same product · DailyMed (U.S. National Library of Medicine)

• Losartan potassium: Losartan and its active metabolite selectively block binding of angiotensin II to the AT1 receptor, blocking its vasoconstrictor and aldosterone-secreting effects (US HYZAAR label).
• Hydrochlorothiazide: Thiazide diuretic that directly increases renal excretion of sodium and chloride in approximately equivalent amounts (US HYZAAR label).