سعر لوزازيد 100/25 مجم 10 اقراص 2024

Losazide 100/25mg 10 f.c. tabs by EIPICO (Egypt): film-coated tablets combining losartan potassium 100 mg (angiotensin II receptor blocker) and hydrochlorothiazide 25 mg (thiazide diuretic) for hypertension.

• Treatment of hypertension, to lower blood pressure and reduce the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy (evidence suggests this benefit does not apply to Black patients).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Controlled trials: upper respiratory infection (6.1% vs 4.6% placebo), dizziness (5.7% vs 2.9%) and back pain (2.1% vs 0.6%) occurred in more than 2% of patients and more often than placebo.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any component; anuria; co-administration with aliskiren in patients with diabetes.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: fetal toxicity - discontinue as soon as possible when pregnancy is detected; drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hypotension in volume- or salt-depleted patients (correct before use); changes in renal function including acute renal failure; electrolyte and metabolic effects (hypokalaemia, hyponatraemia, hyperuricaemia/gout, hyperglycaemia, lipid increases); acute myopia and secondary angle-closure glaucoma (hydrochlorothiazide); exacerbation of systemic lupus erythematosus.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Potassium-sparing diuretics, potassium supplements, salt substitutes and other drugs raising potassiumMay increase serum potassium; monitor.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium concentrations and toxicity; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• NSAIDs including COX-2 inhibitorsMay deteriorate renal function (especially in elderly, volume-depleted or renally impaired patients) and attenuate the antihypertensive effect.DailyMed (U.S. National Library of Medicine)

• Drugs acting on the renin-angiotensin system during the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; discontinue as soon as possible when pregnancy is detected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Thiazides appear in human milk; it is not known whether losartan is excreted in human milk; because of potential adverse effects on the nursing infant, decide whether to discontinue nursing or the drug.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Losartan potassium: Losartan and its principal active metabolite selectively block binding of angiotensin II to the AT1 receptor, blocking its vasoconstrictor and aldosterone-secreting effects; they do not inhibit ACE.
• Hydrochlorothiazide: Thiazide diuretic acting on renal tubular electrolyte reabsorption to increase sodium and chloride excretion; indirectly reduces plasma volume.