سعر كانزارتان بلس 12.5/300مجم 30 قرص 2025

Kansartan Plus 300/12.5 mg film-coated tablets (irbesartan 300 mg + hydrochlorothiazide 12.5 mg), pack of 30, Chemipharm, Egypt.

• Hypertension in patients not adequately controlled with monotherapy, or as initial therapy in patients likely to need multiple drugs to reach blood-pressure goals.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse events (>= 5% and more often than placebo): dizziness, fatigue and musculoskeletal pain.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any component; anuria; hypersensitivity to sulfonamide-derived drugs; coadministration with aliskiren in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning (fetal toxicity): drugs acting directly on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as possible when pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypotension: correct volume or salt depletion before starting treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Monitor renal function and serum potassium in susceptible patients.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• LithiumIncreased serum lithium concentrations and risk of lithium toxicity; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• NSAIDs including selective COX-2 inhibitorsIncreased risk of renal impairment and reduced antihypertensive effect; monitor renal function.DailyMed (U.S. National Library of Medicine)
• Dual RAS blockade (ACE inhibitors, other ARBs, aliskiren)Increased risk of renal impairment, hypotension and hyperkalaemia; aliskiren is contraindicated in patients with diabetes.DailyMed (U.S. National Library of Medicine)

• Boxed warning (fetal toxicity): drugs acting directly on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as possible when pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No data on irbesartan in human milk (present in rat milk); thiazides appear in human milk. Breastfeeding is not recommended because of potential adverse effects in the infant.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Irbesartan: Selectively blocks the binding of angiotensin II to the AT1 receptor, inhibiting its vasoconstrictor and aldosterone-secreting effects.
• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.