سعر مايهيب 400مجم 28 قرص 2022

Myhep sofosbuvir 400 mg tablets, pack of 28 (Mylan / One Pharma Tech); HCV NS5B polymerase inhibitor used as part of combination therapy for chronic hepatitis C.

• Treatment of adults with genotype 1, 2, 3 or 4 chronic hepatitis C without cirrhosis or with compensated cirrhosis, as a component of a combination antiviral regimen.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Treatment of children ≥3 years with genotype 2 or 3 chronic hepatitis C without cirrhosis or with compensated cirrhosis, in combination with ribavirin.Population: Children ≥3 yearsDailyMed (U.S. National Library of Medicine)

• Most common (≥20%): with ribavirin — fatigue and headache; with peginterferon alfa and ribavirin — fatigue, headache, nausea, insomnia and anaemia; in children with ribavirin — decreased appetite.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• When combined with ribavirin or peginterferon alfa/ribavirin, all contraindications of those agents apply to the combination.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: hepatitis B virus reactivation, sometimes fulminant hepatitis, hepatic failure and death, has occurred in HCV/HBV-coinfected patients treated with HCV direct-acting antivirals; test for HBV before treatment and monitor coinfected patients during and after treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serious symptomatic bradycardia (including cases needing a pacemaker and a fatal cardiac arrest with a sofosbuvir-containing regimen) can occur with amiodarone, particularly with beta-blockers, cardiac comorbidity or advanced liver disease; co-administration not recommended, cardiac monitoring if unavoidable.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• AmiodaroneSerious symptomatic bradycardia; co-administration not recommended (cardiac monitoring if no alternative).DailyMed (U.S. National Library of Medicine)
• Intestinal P-gp inducers (e.g. rifampin, St John's wort)May decrease sofosbuvir concentrations and therapeutic effect.DailyMed (U.S. National Library of Medicine)

• No adequate human data for sofosbuvir; no adverse developmental outcomes in animal studies at exposures above human exposure. When given with ribavirin (± peginterferon alfa) the combination is contraindicated in pregnant women and in men whose female partners are pregnant.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Unknown whether sofosbuvir or its metabolites are present in human milk; the main metabolite was found in rat milk without effect on pups; weigh breastfeeding benefits against the mother's need; ribavirin lactation advice applies to combination regimens.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Sofosbuvir: Nucleotide prodrug converted intracellularly to an active uridine analogue triphosphate that is incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator.