سعر سيلوكينزوك 100مجم 28 قرص 2024

Selokenzoc (Seloken ZOC) 100 mg is an AstraZeneca once-daily prolonged-release metoprolol succinate tablet (strength expressed as metoprolol tartrate equivalent), supplied in Egypt as 28 tablets.

• HypertensionPopulation: Adults; children and adolescents 6-18 yearsNAFDAC Greenbook (Nigeria)
• Angina pectorisPopulation: AdultsNAFDAC Greenbook (Nigeria)
• Stable symptomatic chronic heart failure with impaired systolic left ventricular functionPopulation: AdultsNAFDAC Greenbook (Nigeria)

• Very common: fatigue. Common: dizziness, headache, cold extremities, bradycardia, palpitations, exertional dyspnoea, abdominal pain, nausea, vomiting, diarrhoea, constipation. Less common: depression, sleep disturbance, paraesthesia, transient worsening of heart failure, bronchospasm, skin reactions, oedema, weight gain. Rare: thrombocytopenia, visual disturbances, tinnitus, AV conduction prolongation, elevated transaminases, aggravated psoriasis, hair loss.International label, same product · NAFDAC Greenbook (Nigeria)

• Cardiogenic shock; sick sinus syndrome without permanent pacemaker; second- or third-degree AV block; unstable decompensated heart failure or inotropic beta-agonist therapy; symptomatic bradycardia or hypotension (in suspected acute MI: heart rate <45/min, PQ >0.24 s or systolic BP <100 mmHg); serious peripheral vascular disease with gangrene threat; hypersensitivity to metoprolol, other beta-blockers or excipients.International label, same product · NAFDAC Greenbook (Nigeria)

• Avoid abrupt withdrawal: taper over at least two weeks (halving the dose each step down to 12.5 mg for at least 4 days), as sudden withdrawal may worsen heart failure and increase the risk of myocardial infarction and sudden death.International label, same product · NAFDAC Greenbook (Nigeria)
• Do not give intravenous verapamil to patients on beta-blockers; caution in Prinzmetal angina, peripheral arterial disease, asthma/COPD (give bronchodilator therapy), pre-existing AV conduction disorders and phaeochromocytoma (consider an alpha-blocker); may aggravate anaphylaxis treatment; inform the anaesthetist before surgery and avoid acute high-dose initiation in non-cardiac surgery.International label, same product · NAFDAC Greenbook (Nigeria)
• Dizziness and fatigue may occur; consider when driving or operating machinery.International label, same product · NAFDAC Greenbook (Nigeria)

• CYP2D6 inhibitors (quinidine, terbinafine, paroxetine, fluoxetine, sertraline, celecoxib, propafenone, diphenhydramine)May increase metoprolol plasma levels; dose reduction may be needed when starting these drugs.NAFDAC Greenbook (Nigeria)
• Verapamil, diltiazemAdditive inhibition of AV conduction and sinus node function; bradycardia and hypotension (avoid IV verapamil).NAFDAC Greenbook (Nigeria)
• Amiodarone, class I antiarrhythmics, digitalis glycosidesRisk of pronounced bradycardia, conduction delay or additive negative inotropic effects.NAFDAC Greenbook (Nigeria)

• Use in pregnancy and lactation only when considered essential; beta-blockers reduce placental perfusion (associated with growth retardation, intrauterine death, abortion and early labour); maternofetal monitoring is suggested.International label, same product · NAFDAC Greenbook (Nigeria)
• US label: published observational data have not shown a drug-associated risk of major birth defects or miscarriage, but reports of intrauterine growth restriction, preterm birth and perinatal mortality with beta-blocker use are inconsistent; untreated hypertension and heart failure also carry maternal and fetal risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Metoprolol is concentrated in breast milk (about three times the maternal plasma level); risk to the breastfed infant seems low at therapeutic doses, but the infant should be observed for signs of beta-blockade.International label, same product · NAFDAC Greenbook (Nigeria)

• Metoprolol succinate: Beta1-selective receptor blocker: reduces heart rate, cardiac output and blood pressure; selectivity is dose dependent. The ZOC form releases metoprolol from coated pellets at a near-constant rate for about 20 hours.