سعر سوفالدي 400 مجم 28 قرص 2026

Sofosbuvir 400 mg tablets, pack of 28 (Gilead Sciences; Ibis Pharma listed as distributor in Egypt); nucleotide NS5B polymerase inhibitor for chronic hepatitis C.

• Chronic HCV genotype 1, 2, 3 or 4 infection in adults without cirrhosis or with compensated cirrhosis, as a component of a combination antiviral regimen (with ribavirin, or with peginterferon alfa and ribavirin).Population: AdultsDailyMed (U.S. National Library of Medicine)
• Chronic HCV genotype 2 or 3 infection in children aged 3 years and older (with ribavirin).Population: Children 3 years and olderDailyMed (U.S. National Library of Medicine)

• Most common with ribavirin: fatigue and headache; with peginterferon alfa and ribavirin: fatigue, headache, nausea, insomnia and anaemia.International label, same product · DailyMed (U.S. National Library of Medicine)

• When used with ribavirin or peginterferon alfa/ribavirin, all contraindications of those agents apply (including pregnancy and male partners of pregnant women).International label, same product · DailyMed (U.S. National Library of Medicine)

• Boxed warning: hepatitis B virus reactivation (sometimes fulminant) in HCV/HBV co-infected patients; test all patients for HBsAg and anti-HBc before treatment.International label, same product · DailyMed (U.S. National Library of Medicine)
• Serious symptomatic bradycardia with amiodarone, especially with beta-blockers, cardiac comorbidity or advanced liver disease; co-administration not recommended.International label, same product · DailyMed (U.S. National Library of Medicine)
• Intestinal P-gp inducers (e.g., rifampicin, St John's wort) may reduce sofosbuvir levels and efficacy; not recommended.International label, same product · DailyMed (U.S. National Library of Medicine)

• AmiodaroneSerious symptomatic bradycardia; co-administration not recommended, cardiac monitoring if unavoidable.DailyMed (U.S. National Library of Medicine)
• Rifampicin, rifabutin, rifapentine, St John's wort and other intestinal P-gp inducersDecrease sofosbuvir concentrations and may reduce efficacy; not recommended.DailyMed (U.S. National Library of Medicine)

• No adequate human data for sofosbuvir alone; animal studies showed no developmental harm. Combination with ribavirin (with or without peginterferon) is contraindicated in pregnant women and male partners of pregnant women.International label, same product · DailyMed (U.S. National Library of Medicine)
• Unknown whether sofosbuvir passes into human milk (the main metabolite is excreted in rat milk); weigh benefits of breastfeeding against maternal need; ribavirin lactation advice also applies when combined.International label, same product · DailyMed (U.S. National Library of Medicine)

• Sofosbuvir: Nucleotide prodrug converted intracellularly to an active uridine triphosphate analogue that is incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator.