سعر سالبين 750مجم فيال 2024

Sulbin 750mg vial: Egyptian parenteral antibiotic combining ampicillin with the beta-lactamase inhibitor sulbactam, 750 mg powder vial for IM/IV injection (Pharco).

• Injection-site pain (IM 16%, IV 3%), thrombophlebitis 3%, phlebitis 1.2%; diarrhoea 3%, rash <2%; less than 1%: itching, nausea, vomiting, candidiasis, headache and others; raised liver enzymes and haematological changes reported.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• History of serious hypersensitivity (e.g., anaphylaxis, Stevens-Johnson syndrome) to ampicillin, sulbactam or other beta-lactams; previous cholestatic jaundice/hepatic dysfunction associated with ampicillin/sulbactam.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Serious, occasionally fatal anaphylactic reactions; enquire about prior penicillin, cephalosporin or other allergies.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Hepatotoxicity including hepatitis and cholestatic jaundice (deaths reported); monitor hepatic function in hepatic impairment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Severe cutaneous adverse reactions (TEN, SJS, DRESS, AGEP, erythema multiforme); discontinue if lesions progress.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Clostridioides difficile-associated diarrhoea may occur, even over two months after treatment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Avoid in infectious mononucleosis (high rate of skin rash with ampicillin class).General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• ProbenecidDecreases renal tubular secretion of ampicillin and sulbactam, increasing and prolonging blood levels.DailyMed (U.S. National Library of Medicine)
• AllopurinolConcurrent ampicillin and allopurinol substantially increases incidence of rash.DailyMed (U.S. National Library of Medicine)
• AminoglycosidesDo not reconstitute together (in vitro inactivation of aminoglycosides by aminopenicillins).DailyMed (U.S. National Library of Medicine)

• No fetal harm in mouse, rat and rabbit studies up to 10 times the human dose; no adequate studies in pregnant women; use only if clearly needed.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Low concentrations of ampicillin and sulbactam are excreted in milk; use with caution in nursing women.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Hepatic function at regular intervals in patients with hepatic impairment.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Ampicillin: Similar to penicillin in its bactericidal action against susceptible bacteria during active multiplication; acts through inhibition of cell-wall biosynthesis (US label).
• Sulbactam: Irreversibly inhibits a wide range of beta-lactamases; has little useful antibacterial activity alone (except Neisseriaceae) but restores ampicillin activity against beta-lactamase-producing strains (US Unasyn label).