سعر هايزار 50/12.5مجم 14 قرص 2022

Hyzaar 50/12.5 mg film-coated tablets (pack of 14): fixed-dose combination of the angiotensin II receptor blocker losartan potassium and the thiazide diuretic hydrochlorothiazide, listed in Egypt under Merck Sharp & Dohme (Multipharma) as an antihypertensive.

• HypertensionPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Reduction of stroke risk in hypertensive patients with left ventricular hypertrophy (benefit may not apply to Black patients)Population: AdultsDailyMed (U.S. National Library of Medicine)

• In controlled trials, reactions >2% and more frequent than placebo: dizziness (5.7%), upper respiratory infection (6.1%) and back pain (2.1%).International label, same product · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to any component; anuria; coadministration with aliskiren in patients with diabetes.International label, same product · DailyMed (U.S. National Library of Medicine)

• Symptomatic hypotension may occur in volume- or salt-depleted patients; correct depletion before starting.International label, same product · DailyMed (U.S. National Library of Medicine)
• Changes in renal function including acute renal failure may occur, especially with renal artery stenosis, chronic kidney disease, severe heart failure or volume depletion.International label, same product · DailyMed (U.S. National Library of Medicine)
• Electrolyte disturbances: hydrochlorothiazide can cause hypokalemia, hyponatremia and hypomagnesemia; losartan can cause hyperkalemia.International label, same product · DailyMed (U.S. National Library of Medicine)

• Potassium-raising agentsCoadministration with other drugs that raise serum potassium may cause hyperkalemia; monitor potassium.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium and toxicity reported with ARBs or thiazides; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• Aliskiren / ACE inhibitors / other ARBs (dual RAS blockade)Dual RAS blockade increases risks of hypotension, syncope, hyperkalemia and renal function changes.DailyMed (U.S. National Library of Medicine)

• Boxed warning: fetal toxicity. Drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus; discontinue as soon as pregnancy is detected.International label, same product · DailyMed (U.S. National Library of Medicine)
• Unknown whether losartan passes into human milk (present in rat milk); thiazides appear in human milk. Decide whether to discontinue nursing or the drug.International label, same product · DailyMed (U.S. National Library of Medicine)

• Losartan potassium: Losartan and its active metabolite block binding of angiotensin II to the AT1 receptor, opposing its vasoconstrictor and aldosterone-secreting effects.
• Hydrochlorothiazide: Thiazide diuretic that increases renal excretion of sodium and chloride.