سعر لوراز فورت 100/25مجم 14 قرص 2024

Loraz forte 100/25mg 28 tab by EGPI (Egypt): tablets combining losartan potassium 100 mg (angiotensin II receptor blocker) and hydrochlorothiazide 25 mg (thiazide diuretic) for hypertension.

• Treatment of hypertension, to lower blood pressure and reduce the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy (evidence suggests this benefit does not apply to Black patients).Population: AdultsDailyMed (U.S. National Library of Medicine)
• Essential hypertension in patients whose blood pressure is not adequately controlled on losartan or hydrochlorothiazide alone (not for initial therapy).Population: Adultselectronic medicines compendium (emc), UK

• US controlled trials: upper respiratory infection (6.1%), dizziness (5.7%) and back pain (2.1%) were the reactions more frequent than placebo in at least 2% of patients.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• US: hypersensitivity to any component; anuria; co-administration with aliskiren in patients with diabetes.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• UK: hypersensitivity to losartan, sulphonamide-derived substances (such as hydrochlorothiazide) or excipients; therapy-resistant hypokalaemia or hypercalcaemia; severe hepatic impairment, cholestasis and biliary obstructive disorders; refractory hyponatraemia; symptomatic hyperuricaemia/gout; 2nd and 3rd trimesters of pregnancy; severe renal impairment (CrCl <30 ml/min); anuria; aliskiren in diabetes or renal impairment (GFR <60 ml/min/1.73 m2).International label, equivalent formulation · electronic medicines compendium (emc), UK

• Boxed warning (US): fetal toxicity - discontinue as soon as possible when pregnancy is detected; drugs acting on the renin-angiotensin system can cause injury and death to the developing fetus.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• US: hypotension in volume- or salt-depleted patients (correct before use); changes in renal function including acute renal failure; electrolyte and metabolic effects (hypokalaemia, hyponatraemia, hyperuricaemia/gout, hyperglycaemia, lipid increases); acute myopia and secondary angle-closure glaucoma (hydrochlorothiazide); exacerbation of systemic lupus erythematosus.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• UK: non-melanoma skin cancer (basal cell and squamous cell carcinoma) risk increases with cumulative hydrochlorothiazide dose; advise sun protection and regular skin checks.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Potassium-sparing diuretics, potassium supplements, salt substitutes and other drugs raising potassiumMay increase serum potassium; monitor.DailyMed (U.S. National Library of Medicine)
• LithiumIncreased serum lithium concentrations and toxicity; monitor lithium levels.DailyMed (U.S. National Library of Medicine)
• NSAIDs including COX-2 inhibitorsMay deteriorate renal function (especially in elderly, volume-depleted or renally impaired patients) and attenuate the antihypertensive effect.DailyMed (U.S. National Library of Medicine)

• US: drugs acting on the renin-angiotensin system during the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death; discontinue as soon as possible when pregnancy is detected.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• UK: not recommended during breastfeeding; hydrochlorothiazide is excreted in small amounts in milk and high doses may inhibit milk production.International label, equivalent formulation · electronic medicines compendium (emc), UK
• US: thiazides appear in human milk; it is not known whether losartan is excreted in human milk; because of potential adverse effects on the nursing infant, decide whether to discontinue nursing or the drug.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Losartan potassium: Losartan and its principal active metabolite selectively block binding of angiotensin II to the AT1 receptor, blocking its vasoconstrictor and aldosterone-secreting effects; they do not inhibit ACE.
• Hydrochlorothiazide: Thiazide diuretic acting on renal tubular electrolyte reabsorption to increase sodium and chloride excretion; indirectly reduces plasma volume.