سعر مافيلور 10 مجم 2024

Nebivolol 10 mg tablets (Multi-Apex, Egypt), a selective beta-1 blocker used for hypertension; pack of 30 tablets.

• Treatment of hypertension, to lower blood pressure; may be used alone or with other antihypertensive agents.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Adverse reactions in hypertension trials (at least 1% and more often than placebo in at least one dose group) included headache, fatigue, dizziness, diarrhoea, nausea, insomnia, peripheral oedema, chest pain, bradycardia, dyspnoea and rash.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Laboratory changes in controlled trials: increases in BUN, uric acid and triglycerides and decreases in HDL cholesterol and platelet count.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Contraindicated in severe bradycardia, heart block greater than first degree, cardiogenic shock, decompensated cardiac failure, sick sinus syndrome (unless a permanent pacemaker is in place), severe hepatic impairment (Child-Pugh >B) and hypersensitivity to any component.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Do not stop abruptly in coronary artery disease: severe worsening of angina, myocardial infarction and ventricular arrhythmias have followed abrupt beta-blocker withdrawal; taper over 1 to 2 weeks when possible.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• In general, patients with bronchospastic diseases should not receive beta-blockers.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Beta-blockers may mask early signs of hypoglycaemia such as tachycardia and increase the risk of severe or prolonged hypoglycaemia, especially in diabetes, children and fasting patients.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CYP2D6 inhibitors (e.g. quinidine, propafenone, fluoxetine, paroxetine)Increase nebivolol exposure; use with caution and the nebivolol dose may need to be reduced.DailyMed (U.S. National Library of Medicine)
• Other beta-blockersDo not use nebivolol with other beta-blockers.DailyMed (U.S. National Library of Medicine)
• Catecholamine-depleting drugs (reserpine, guanethidine)Added beta-blockade may cause excessive reduction of sympathetic activity; monitor closely.DailyMed (U.S. National Library of Medicine)

• Available human data are insufficient to determine drug-associated risks; poorly controlled hypertension in pregnancy carries maternal and fetal risks. In rats, oral nebivolol during organogenesis caused embryofetal and perinatal lethality at doses about equal to the maximum recommended human dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No information on presence in human milk; nebivolol is present in rat milk. Because beta-blockers can cause serious adverse reactions in nursing infants, especially bradycardia, it is not recommended during nursing.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Nebivolol: Beta-adrenergic receptor blocker; the antihypertensive mechanism is not definitively established and may involve decreased heart rate and myocardial contractility, reduced sympathetic outflow, renin suppression and vasodilation with decreased peripheral vascular resistance (US BYSTOLIC label).