سعر نورفاسك 5مجم 10 قرص 2022

Norvasc 5 mg tablets (Pfizer, Egypt): amlodipine 5 mg per tablet, a dihydropyridine calcium channel blocker for hypertension and angina; pack of 10 tablets.

• Hypertension, to lower blood pressurePopulation: Adults (hypertension also pediatric 6-17 years)DailyMed (NLM)
• Chronic stable anginaPopulation: Adults (hypertension also pediatric 6-17 years)DailyMed (NLM)
• Confirmed or suspected vasospastic (Prinzmetal) anginaPopulation: Adults (hypertension also pediatric 6-17 years)DailyMed (NLM)

• Dose-related: edema (10.8% at 10 mg), dizziness, flushing, palpitation; also fatigue, nausea, abdominal pain, somnolence.International label, same formulation · DailyMed (NLM)

• Known sensitivity to amlodipine.International label, same formulation · DailyMed (NLM)

• Symptomatic hypotension is possible, particularly with severe aortic stenosis.International label, same formulation · DailyMed (NLM)
• Worsening angina and acute myocardial infarction can develop after starting or increasing the dose, particularly with severe obstructive coronary artery disease.International label, same formulation · DailyMed (NLM)

• CYP3A inhibitors (moderate and strong)Increase amlodipine exposure; monitor for hypotension and edema; dose reduction may be needed.DailyMed (NLM)
• CYP3A inducersQuantitative effect unknown; monitor blood pressure closely.DailyMed (NLM)
• SimvastatinLimit simvastatin to 20 mg daily.DailyMed (NLM)

• Limited post-marketing data are insufficient to inform a drug-associated risk of major birth defects or miscarriage; poorly controlled hypertension in pregnancy carries maternal and fetal risks.International label, same formulation · DailyMed (NLM)
• Amlodipine is present in human milk (median relative infant dose 4.2%); no adverse effects observed in breastfed infants; no data on milk production.International label, same formulation · DailyMed (NLM)

• Amlodipine: Dihydropyridine calcium antagonist that inhibits transmembrane calcium influx, with a greater effect on vascular smooth muscle than cardiac muscle; reduces peripheral vascular resistance and blood pressure.