سعر سوفوفيروتال 2022

Sofovirotal 400 mg is an Egyptian sofosbuvir oral tablet (28 tablets per pack) listed by Egyptian directories under Future Pharmaceutical Industries (FPI), used for chronic hepatitis C as part of combination therapy.

• Treatment of adults with genotype 1, 2, 3 or 4 chronic HCV infection without cirrhosis or with compensated cirrhosis, as a component of a combination antiviral regimen.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common with ribavirin: fatigue and headache; with peginterferon alfa and ribavirin: fatigue, headache, nausea, insomnia and anaemia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• When used with peginterferon alfa/ribavirin or ribavirin alone, all contraindications of those agents also apply (including pregnancy).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: hepatitis B virus reactivation (sometimes fulminant hepatitis, hepatic failure and death) in HCV/HBV coinfected patients; test all patients for HBsAg and anti-HBc before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serious symptomatic bradycardia may occur when amiodarone is co-administered with a sofosbuvir-containing regimen; co-administration is not recommended.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• AmiodaroneSerious symptomatic bradycardia; co-administration not recommended.DailyMed (U.S. National Library of Medicine)
• Intestinal P-gp inducers (e.g. rifampin, St John's wort)May reduce sofosbuvir concentrations.DailyMed (U.S. National Library of Medicine)

• No adequate human data; no adverse developmental outcomes in animal studies with sofosbuvir. Combination with ribavirin is contraindicated in pregnant women and in men whose female partners are pregnant.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Not known whether sofosbuvir or metabolites are present in human milk; weigh benefits of breastfeeding against clinical need (ribavirin information also applies when combined).International label, same formulation · DailyMed (U.S. National Library of Medicine)

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