سعر تنسوبليرون Tensopleron‏ 25مجم 20 قرص 2026

Eplerenone 25 mg film-coated tablets, pack of 20 (Global Pharmaceutical Industries, Egypt); selective aldosterone receptor antagonist.

• More frequent than placebo in post-MI HF (EPHESUS): hyperkalaemia (3.4% vs 2.0%) and increased creatinine (2.4% vs 1.5%); in hypertension gynaecomastia and abnormal vaginal bleeding were reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• All patients: serum potassium >5.5 mEq/L at initiation; creatinine clearance <=30 mL/min; strong CYP3A inhibitors (e.g. ketoconazole, itraconazole, clarithromycin, ritonavir, nelfinavir). Hypertension additionally: type 2 diabetes with microalbuminuria; serum creatinine >2.0 mg/dL (men) or >1.8 mg/dL (women); CrCl <50 mL/min; potassium supplements or potassium-sparing diuretics.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hyperkalaemia: risk is higher with impaired renal function, proteinuria, diabetes and concomitant ACE inhibitors, ARBs, NSAIDs or moderate CYP3A inhibitors.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A inhibitorsContraindicated; eplerenone is metabolised mainly by CYP3A.DailyMed (U.S. National Library of Medicine)
• ACE inhibitors / angiotensin II receptor blockersIncreased risk of hyperkalaemia; monitor potassium and renal function.DailyMed (U.S. National Library of Medicine)

• Published case reports are insufficient to establish a drug-associated risk of major birth defects, miscarriage or adverse outcomes; no developmental effects in rats and rabbits at about 30 times human exposure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No human data on presence in milk; eplerenone was present in rat milk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

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