سعر هيباكلود 0.5 مجم / 10 مل محلول 210 مل 2022

Entecavir oral solution 0.5 mg/10 ml (0.05 mg/ml), 210 ml bottle (Hepaclude, Chemipharm), a nucleoside analogue HBV polymerase inhibitor for chronic hepatitis B.

• Chronic hepatitis B virus infection with active viral replication and elevated aminotransferases or histologically active diseasePopulation: Adults and children 2 years and olderDailyMed (U.S. National Library of Medicine)

• Most common (>=3%) in adults with compensated liver disease: headache, fatigue, dizziness and nausea.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• None (US label).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: severe acute exacerbations of hepatitis B after discontinuation - monitor hepatic function closely for at least several months after stopping.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• HIV/HBV co-infection: not recommended unless the patient also receives effective HIV treatment (risk of HIV NRTI resistance); offer HIV testing before starting.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with nucleoside analogues; suspend treatment if suggestive findings develop.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Drugs that reduce renal function or compete for active tubular secretionMay increase serum concentrations of entecavir or the co-administered drug; monitor closely.DailyMed (U.S. National Library of Medicine)
• Lamivudine, adefovir dipivoxil, tenofovir disoproxil fumarateCo-administration did not result in significant drug interactions.DailyMed (U.S. National Library of Medicine)

• Antiretroviral Pregnancy Registry data are insufficient to assess the risk of birth defects, miscarriage or adverse outcomes; no adverse developmental effects in animal studies at clinically relevant exposures. A pregnancy exposure registry exists.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Unknown whether present in human milk (present in rat milk at about 25% of plasma); weigh breastfeeding benefits against the mother's need for treatment and potential infant effects.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Entecavir: Guanosine nucleoside analogue; its triphosphate competes with deoxyguanosine triphosphate and inhibits HBV polymerase base priming, reverse transcription of the negative strand and positive-strand HBV DNA synthesis.