سعر كلودين تك 1 مجم 10 كبسولات 2024

Cludinetech 1mg 10 h.g.cap: Entecavir 1 mg (European egyptian pharm. ind. > pharma-tech).

• Chronic hepatitis B virus infection in adults and paediatric patients with evidence of active viral replication and persistent elevations in serum aminotransferases or histologically active disease (US BARACLUDE labeling). Confirm Egyptian leaflet for approved ages/indications.Population: Adults and paediatric patients per US labelDailyMed (NLM)

• Common adverse reactions include headache, fatigue, dizziness and nausea; monitor hepatic function during and after therapy (US label).International label, equivalent formulation · DailyMed (NLM)

• Hypersensitivity to entecavir or any component of the product (US label).International label, equivalent formulation · DailyMed (NLM)

• Boxed warning: severe acute exacerbations of hepatitis B after discontinuation; lactic acidosis and severe hepatomegaly with steatosis (including fatal cases) reported with nucleoside analogues; HIV co-infection — may cause HIV resistance if used without antiretroviral therapy (US BARACLUDE).International label, equivalent formulation · DailyMed (NLM)

• Drugs that reduce renal function / compete for active tubular secretionModerateMay increase entecavir or coadministered drug concentrations; monitor for toxicity.DailyMed (NLM)

• Use in pregnancy only if clearly needed; limited human data; animal studies have shown no evidence of fetal harm at higher exposures — follow current PLLR-style US labeling and local guidance.International label, equivalent formulation · DailyMed (NLM)
• It is not known whether entecavir is excreted in human milk; consider risks/benefits of breastfeeding during therapy (US label).International label, equivalent formulation · DailyMed (NLM)

• Entecavir: Guanosine nucleoside analogue; the triphosphate competes with deoxyguanosine triphosphate and inhibits HBV polymerase base priming, reverse transcription of the negative strand and positive-strand HBV DNA synthesis.